Jackson scored 27, Joe Trapani added 22 points and Biko Paris had 21 for the fifth-seeded Eagles (20-11).
They shot nearly 54 percent on 29-of-54 shooting, made 10 3-pointers and used a huge first-half run to boost their NCAA tournament chances and blow out Wake Forest for the second time this week.
The Eagles will face fourth-seeded Clemson on Friday in a quarterfinal matchup of NCAA bubble teams.
Travis McKie had 16 points and 12 rebounds for the 12th-seeded Demon Deacons (8-24), who haven’t won an ACC tournament game since 2007. They never led and capped the losingest season in school history with their 11th straight defeat.