Grant, the son of former Oklahoma standout Harvey, made nearly everything he shot and so did the Tigers (13-4, 2-1 ACC), who finished with their highest shooting percentage (69.2) against an ACC opponent in 57 years of league play.
Grant was 5 of 6 from the field and 10 of 12 from the line, surpassing his previous best of 19 set last month in a win over UNC Greensboro.
Clemson finished 27 of 39 from the field, including 9 of 9 on 3-pointers in the second half.
It was that shooting touch that sunk Georgia Tech (7-8, 0-2).
The game was originally scheduled for Tuesday night but delayed because of the snowstorm that struck the Southeast this week.
The cold weather didn't bother the Tigers. Stitt and Smith scored 16 points apiece as the five Clemson starters scored in double figures.
Jordan Williams added 13 points and matched a season-high with 15 rebounds for his 10th consecutive double-double, and Adrian Bowie scored 12 points for the Terrapins.
Maryland (11-5, 1-2 ACC) shot 38 percent, hitting 26 of 68 attempts, outrebounded Wake Forest 52-42 and used a 15-0 spurt midway through the second half to take command and avoid an 0-3 start to league play.
Freshman Travis McKie had 13 points and 10 rebounds, and C.J. Harris added 10 points for the Demon Deacons (7-10, 0-2).