He was diagnosed with Ewing's Sarcoma, a rare form of cancer, the next spring and missed all of last season.
In 2008 Herzlich was a First-team All-American and the ACC Defensive Player of the Year. He was also a finalist for the Butkus Award, and a quarter finalist for the Lott Trophy.
Herzlich led the team with 110 tackles and 81 stops, six interceptions, eight pass break-ups, two forced fumbles, and two fumble recoveries and also had 13 tackles for a loss. In November 2008, Herzlich was ranked as the 45th best prospect for the 2009 NFL Draft but announced his return to Boston College for the 2009 season which was subsequently interrupted by the disease.