However, 7-foot-1 junior Brian Zoubek will play despite a broken nose suffered against the Seminoles.
Smith has missed the past two games and has not been practicing, though the Blue Devils can play Jon Scheyer and Greg Paulus at the point. Thomas' health could be a bigger problem considering Duke doesn't have as much depth on the interior, an area the Tar Heels have an advantage with reigning national player of the year Tyler Hansbrough, junior Deon Thompson, and freshmen Ed Davis and Tyler Zeller.
The 6-foot-8 Thomas hurt his left ankle after less than a minute of action in the first half against the Seminoles and did not return. He lightly ran in Friday's practice, though Krzyzewski said it was only at about 75 percent and that Thomas would need to practice Saturday in order to play.